A systems-based protocol:
A disciplined, scientific approach is required to understand, stage, treat and monitor disease at the cellular level. Expanding upon conventional diagnostic methods, recent discoveries have presented the opportunity to seek out disease at it origins. A carefully-designed protocol evaluates and classifies the disease state and its characteristics. Nutritional agents are selected and matched according to their effectiveness to treat specific cellular functions. All agents are supported by validated, credible research to act upon a specific cellular function and associated signaling pathway(s).

Coefficients:
It is imperative that we develop and institute treatment protocols that can accommodate and integrate key influencing factors impacting
disease kinetics and outcomes. Coefficients assigned to these factors provide a higher level of precision that enables more precise objectives for outcomes and time-frames.

Bioavailability:
The effectiveness of every nutritional agent can become irrelevant if the agent does not reach the target in sufficient quantities and the proper chemical property or metabolite. As an example, recent advances in nano-encapsulation technologies have been measured to increase bioavailablity of nutritional agents by factors of 10x to 50x. Disease kinetics and tissue (tumor) volume Characteristics of disease at the cellular level, many mirroring well known cancer hallmarks are calculated and quantified to understand the current nature of the disease, its aggressiveness, resilience, tissue volume, etc. Newly discovered disease functions at the cell level must be recognized, evaluated and assigned a level of importance regarding their influence upon the behavior of the disease and the effectiveness of the nutritional regimen.

Agent synergy:
Many nutritional agents have been shown to have synergistic effects when combined with other nutritional agents for specific diseases or for health in general. Agents have been shown to act on specific pathways and targets in cell disease biology. By combining agents it is possible to affect several disease processes in parallel, resulting in a much more powerful influence to bring about healing to a greater degree, in a shorter time frame.

There has been extensive research and discovery identifying, classifying and mapping cell signaling within the cell and the cellular environment. Nutritional agents have been shown to act upon specific cellular functions which are reflected in the modification of distinct signaling pathways. Matching the agents to a specific function and pathway provides the opportunity to project and quantify outcomes at the cell level in addition to identifying the impact upon disease hallmarks, symptoms and progression.